Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9NP90
UPID:
RAB9B_HUMAN
Alternative names:
Rab-9-like protein
Alternative UPACC:
Q9NP90; B2R8M0; Q52LX2
Background:
The Ras-related protein Rab-9B, also known as Rab-9-like protein, plays a crucial role in the transport of proteins between the endosomes and the trans Golgi network. This protein is a key component in the intracellular trafficking system, ensuring the proper delivery of proteins to their designated locations within the cell.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-9B could open doors to potential therapeutic strategies. Its pivotal function in protein transport within cells highlights its importance in maintaining cellular homeostasis and function.