Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9NPA8
UPID:
ENY2_HUMAN
Alternative names:
Enhancer of yellow 2 transcription factor homolog
Alternative UPACC:
Q9NPA8; B2RE52; G3V117
Background:
Transcription and mRNA export factor ENY2, also known as Enhancer of yellow 2 transcription factor homolog, plays a pivotal role in gene expression. It is integral to mRNA export coupled with transcription activation, associating with both the TREX-2 and the SAGA complexes. Within the SAGA complex, ENY2 contributes to a subcomplex focused on deubiquitinating histones H2A and H2B, essential for chromatin remodeling and transcription activation. Its involvement is crucial for nuclear receptor-mediated transactivation and the export of mRNAs to the cytoplasm.
Therapeutic significance:
Understanding the role of Transcription and mRNA export factor ENY2 could open doors to potential therapeutic strategies.