Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9P0J7
UPID:
KCMF1_HUMAN
Alternative names:
FGF-induced in gastric cancer; Potassium channel modulatory factor; RING-type E3 ubiquitin transferase KCMF1; ZZ-type zinc finger-containing protein 1
Alternative UPACC:
Q9P0J7; Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9UFE8
Background:
E3 ubiquitin-protein ligase KCMF1, also known as FGF-induced in gastric cancer, Potassium channel modulatory factor, RING-type E3 ubiquitin transferase KCMF1, and ZZ-type zinc finger-containing protein 1, plays a crucial role in cellular processes through its intrinsic E3 ubiquitin ligase activity, promoting ubiquitination. This activity is pivotal for protein degradation, signal transduction, and cell cycle regulation.
Therapeutic significance:
Understanding the role of E3 ubiquitin-protein ligase KCMF1 could open doors to potential therapeutic strategies. Its involvement in key cellular processes highlights its potential as a target for drug discovery, aiming to modulate its ubiquitin ligase activity for therapeutic benefits.