Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9UKX5
UPID:
ITA11_HUMAN
Alternative names:
-
Alternative UPACC:
Q9UKX5; J3KQM2; Q8WYI8; Q9UKQ1
Background:
Integrin alpha-11, encoded by the gene symbol Q9UKX5, plays a pivotal role in cell adhesion and signaling by serving as a receptor for collagen. This protein is part of the integrin family, which are transmembrane receptors that facilitate cell-ECM (extracellular matrix) adhesion, crucial for physiological processes including tissue repair, immune response, and embryonic development.
Therapeutic significance:
Understanding the role of Integrin alpha-11 could open doors to potential therapeutic strategies. Its involvement in cell adhesion and signaling pathways highlights its potential as a target for modulating disease-related cell interactions and pathological tissue remodeling.