Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9Y256
UPID:
FACE2_HUMAN
Alternative names:
Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog
Alternative UPACC:
Q9Y256; Q52LZ9
Background:
CAAX prenyl protease 2, also known as Farnesylated proteins-converting enzyme 2 and RCE1 homolog, plays a crucial role in cellular processes by proteolytically removing the C-terminal three residues of farnesylated and geranylated proteins. This enzyme is capable of processing key signaling molecules such as K-Ras, N-Ras, H-Ras, RAP1B, and G-gamma-1, which are pivotal in cell signaling pathways.
Therapeutic significance:
Understanding the role of CAAX prenyl protease 2 could open doors to potential therapeutic strategies. Its involvement in processing critical signaling proteins suggests a significant impact on cellular functions and disease mechanisms.