Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y277
UPID:
VDAC3_HUMAN
Alternative names:
Outer mitochondrial membrane protein porin 3
Alternative UPACC:
Q9Y277; Q9UIS0
Background:
Voltage-dependent anion-selective channel protein 3 (VDAC3), also known as Outer mitochondrial membrane protein porin 3, plays a crucial role in forming a channel through the mitochondrial outer membrane. This channel facilitates the diffusion of small hydrophilic molecules, essential for cellular energy metabolism and ion homeostasis. VDAC3's involvement in male fertility and sperm mitochondrial sheath formation highlights its significance in reproductive biology.
Therapeutic significance:
Understanding the role of Voltage-dependent anion-selective channel protein 3 could open doors to potential therapeutic strategies. Its pivotal function in energy metabolism and reproductive biology positions it as a key target for research in metabolic disorders and infertility treatments.