Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y4C0
UPID:
NRX3A_HUMAN
Alternative names:
Neurexin III-alpha; Neurexin-3-alpha
Alternative UPACC:
Q9Y4C0; A6NGR4; A7MD34; O95378; Q8IUE3; Q9NS47; Q9P1V3; Q9P1V6; Q9UIE2; Q9UIE3; Q9ULA5; Q9Y486
Background:
Neurexin-3, also known as Neurexin III-alpha and Neurexin-3-alpha, is a neuronal cell surface protein implicated in cell recognition and adhesion. It is believed to play a role in mediating intracellular signaling, showcasing its importance in neural communication and synaptic function.
Therapeutic significance:
Understanding the role of Neurexin-3 could open doors to potential therapeutic strategies. Its involvement in cell adhesion and signaling pathways highlights its potential as a target for interventions in neurological disorders.