Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y561
UPID:
LRP12_HUMAN
Alternative names:
Suppressor of tumorigenicity 7 protein
Alternative UPACC:
Q9Y561; A8K137; B4DRQ2
Background:
Low-density lipoprotein receptor-related protein 12, also known as Suppressor of tumorigenicity 7 protein, plays a crucial role in the internalization of lipophilic molecules and signal transduction. Its potential as a tumor suppressor highlights its importance in cellular mechanisms.
Therapeutic significance:
Linked to Oculopharyngodistal myopathy 1, a muscle disorder with autosomal dominant inheritance, this protein's mutation suggests a direct pathway for therapeutic intervention. Understanding its role could revolutionize treatment strategies for this debilitating condition.