Focused On-demand Library for Kallikrein-4

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Enamel matrix serine proteinase 1; Kallikrein-like protein 1; Prostase; Serine protease 17

Alternative UPACC:

Q9Y5K2; Q4VB16; Q96RU5; Q9GZL6; Q9UBJ6


Kallikrein-4, also known as Enamel matrix serine proteinase 1, plays a pivotal role in enamel formation, crucial for dental health. It is instrumental during the maturation stage of tooth development, facilitating the clearance of enamel proteins and ensuring the normal structural patterning of the crystalline matrix.

Therapeutic significance:

Kallikrein-4's malfunction is linked to Amelogenesis imperfecta, hypomaturation type, 2A1, a condition affecting enamel formation, leading to softer enamel with a distinctive brown pigment. Understanding the role of Kallikrein-4 could open doors to potential therapeutic strategies for this dental disorder.

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