Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9Y623
UPID:
MYH4_HUMAN
Alternative names:
Myosin heavy chain 2b; Myosin heavy chain 4; Myosin heavy chain IIb; Myosin heavy chain, skeletal muscle, fetal
Alternative UPACC:
Q9Y623
Background:
Myosin-4, known by alternative names such as Myosin heavy chain 2b, Myosin heavy chain 4, Myosin heavy chain IIb, and Myosin heavy chain, skeletal muscle, fetal, plays a pivotal role in muscle contraction. This protein is essential for the movement and strength of muscles, showcasing its fundamental role in the musculoskeletal system.
Therapeutic significance:
Understanding the role of Myosin-4 could open doors to potential therapeutic strategies. Its critical function in muscle contraction positions it as a key target for interventions in muscle-related disorders, offering a promising avenue for drug discovery and development.