Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9Y6G1
UPID:
TM14A_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y6G1; B2R552
Background:
Transmembrane protein 14A plays a crucial role in cellular survival by inhibiting apoptosis. It achieves this through the negative regulation of mitochondrial outer membrane permeabilization, a key process in the apoptotic signaling pathway. This protein's ability to control cell death mechanisms positions it as a significant player in cellular health and disease.
Therapeutic significance:
Understanding the role of Transmembrane protein 14A could open doors to potential therapeutic strategies. Its pivotal function in preventing apoptosis underscores its potential as a target for interventions in diseases where cell survival is compromised.