Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9Y6L7
UPID:
TLL2_HUMAN
Alternative names:
-
Alternative UPACC:
Q9Y6L7; A6NDK0; Q2M1H1; Q6PJN5; Q9UQ00
Background:
Tolloid-like protein 2 plays a crucial role in embryonic development, acting as the predominant protease. It specifically processes pro-lysyl oxidase, a critical step in the development process, influencing dorsal-ventral patterning and skeletogenesis. This protein's unique function underscores its importance in the early stages of development.
Therapeutic significance:
Understanding the role of Tolloid-like protein 2 could open doors to potential therapeutic strategies. Its pivotal role in embryonic development highlights its potential as a target for therapeutic intervention in developmental disorders.