Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A0A1B0GTQ4
UPID:
MYMX_HUMAN
Alternative names:
Microprotein inducer of fusion
Alternative UPACC:
A0A1B0GTQ4; A0A223PZB9
Background:
Protein myomixer, also known as Microprotein inducer of fusion, plays a pivotal role in muscle development. It mediates myoblast fusion, a critical process for forming multi-nucleated muscle fibers, essential for muscle growth and repair. This protein operates by generating membrane stresses that drive fusion pore formation, acting independently of MYMK and is crucial in skeletal muscle regeneration post-injury.
Therapeutic significance:
Given its involvement in Carey-Fineman-Ziter syndrome 2, a disorder marked by facial musculature weakness and skeletal abnormalities, understanding the role of Protein myomixer could open doors to potential therapeutic strategies for muscle-related diseases.