Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A4D1P6
UPID:
WDR91_HUMAN
Alternative names:
-
Alternative UPACC:
A4D1P6; A6NK54; C9JMI4; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6
Background:
WD repeat-containing protein 91 (WDR91) plays a crucial role in cellular processes by acting as a negative regulator of PI3 kinase/PI3K activity associated with endosomal membranes. It influences the phosphatidylinositol 3-phosphate content of endosomal membranes, impacting endosome fusion, recycling, sorting, and transport. WDR91 is essential for the delivery of cargos like BST2/tetherin from early to late endosome, facilitating their lysosomal degradation. It also has a potential role in meiosis.
Therapeutic significance:
Understanding the role of WD repeat-containing protein 91 could open doors to potential therapeutic strategies.