Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
A6NDI0
UPID:
TR49B_HUMAN
Alternative names:
RING finger protein 18B
Alternative UPACC:
A6NDI0
Background:
The Putative tripartite motif-containing protein 49B, also known as RING finger protein 18B, represents a unique entity within the protein universe. Its sequence and structural motifs suggest a role in ubiquitin-mediated pathways, which are crucial for protein degradation and signaling. The tripartite motif, consisting of a RING domain, one or two B-box domains, and a coiled-coil region, indicates potential involvement in protein-protein interactions, regulation of transcription, and apoptosis.
Therapeutic significance:
Understanding the role of Putative tripartite motif-containing protein 49B could open doors to potential therapeutic strategies. Its involvement in ubiquitin-mediated pathways hints at its importance in cellular homeostasis and disease mechanisms. Targeting such a protein could lead to novel approaches in treating diseases where protein degradation and signaling pathways are disrupted.