Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
A6NGU5
UPID:
GGT3_HUMAN
Alternative names:
Gamma-glutamyltransferase 3; Putative gamma-glutamyltranspeptidase 3
Alternative UPACC:
A6NGU5
Background:
Putative glutathione hydrolase 3 proenzyme, also known as Gamma-glutamyltransferase 3 and Putative gamma-glutamyltranspeptidase 3, plays a crucial role in cellular processes by hydrolyzing and transferring gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. This enzymatic activity is vital for maintaining cellular homeostasis and detoxification.
Therapeutic significance:
Understanding the role of Putative glutathione hydrolase 3 proenzyme could open doors to potential therapeutic strategies. Its involvement in crucial cellular detoxification processes highlights its potential as a target for developing treatments aimed at enhancing cellular resilience and combating diseases linked to oxidative stress and toxin accumulation.