Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A6NIH7
UPID:
U119B_HUMAN
Alternative names:
-
Alternative UPACC:
A6NIH7
Background:
Protein unc-119 homolog B is a myristoyl-binding protein essential for the localization of specific N-terminally myristoylated proteins. It plays a pivotal role in the proper functioning of photoreceptor cells by trafficking proteins, including the localization of NPHP3 to the primary cilium membrane. Its selective binding to myristoylated proteins underscores its specificity and importance in cellular processes.
Therapeutic significance:
Understanding the role of Protein unc-119 homolog B could open doors to potential therapeutic strategies. Its critical function in protein localization and trafficking in photoreceptor cells highlights its potential in addressing retinal diseases.