Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
B0I1T2
UPID:
MYO1G_HUMAN
Alternative names:
-
Alternative UPACC:
B0I1T2; Q8TEI9; Q8TES2; Q96BE2; Q96RI5; Q96RI6
Background:
Unconventional myosin-Ig plays a pivotal role in immune surveillance by regulating T-cell migration and enhancing the detection of rare antigens in lymph nodes. This actin-based motor molecule with ATPase activity is crucial for intracellular movements and membrane tension generation. It also supports B-cell functions and Fc-gamma receptor phagocytosis, underscoring its importance in immune response.
Therapeutic significance:
Understanding the role of Unconventional myosin-Ig could open doors to potential therapeutic strategies.