Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
D6R9N7
UPID:
U17LI_HUMAN
Alternative names:
-
Alternative UPACC:
D6R9N7
Background:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 plays a pivotal role in cellular processes by acting as a deubiquitinating enzyme. It meticulously removes conjugated ubiquitin from specific proteins, thereby regulating cell proliferation, cell cycle progression, apoptosis, cell migration, and the cellular response to viral infection. This protein's ability to modulate ubiquitination is crucial for maintaining cellular homeostasis and responding to environmental cues.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 could open doors to potential therapeutic strategies. Its involvement in key cellular processes suggests that modulating its activity could offer new avenues for treating diseases related to cell cycle dysregulation, apoptosis, and viral infections.