Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O00141
UPID:
SGK1_HUMAN
Alternative names:
Serum/glucocorticoid-regulated kinase 1
Alternative UPACC:
O00141; B7UUP7; B7UUP8; B7UUP9; B7Z5B2; E1P583; Q5TCN2; Q5TCN3; Q5TCN4; Q5VY65; Q9UN56
Background:
Serine/threonine-protein kinase Sgk1, also known as Serum/glucocorticoid-regulated kinase 1, plays a pivotal role in regulating ion channels, membrane transporters, and various cellular processes including growth, survival, and apoptosis. It is crucial in the stress response and affects renal Na(+) retention, K(+) elimination, and insulin-dependent blood pressure regulation. Sgk1's influence extends to enhancing the stability and expression of Na(+) channels and regulating calcium entry through phosphorylation of key proteins.
Therapeutic significance:
Understanding the role of Serine/threonine-protein kinase Sgk1 could open doors to potential therapeutic strategies. Its involvement in a wide array of cellular functions and regulatory mechanisms positions it as a key target for drug discovery efforts aimed at addressing disorders related to ion channel dysregulation and cellular stress responses.