Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O00170
UPID:
AIP_HUMAN
Alternative names:
Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; Immunophilin homolog ARA9
Alternative UPACC:
O00170; A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; Q2M3Q2; Q99606
Background:
The AH receptor-interacting protein, also known as Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, and Immunophilin homolog ARA9, plays a crucial role in AHR-mediated signaling and acts as a cellular negative regulator of the hepatitis B virus (HBV) X protein. Its involvement in these processes highlights its importance in cellular signaling and viral response mechanisms.
Therapeutic significance:
Given its role in pituitary adenoma 1, multiple types, a common neuroendocrine tumor, understanding the AH receptor-interacting protein's function could pave the way for innovative treatments targeting this and potentially other related diseases.