Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O00178
UPID:
GTPB1_HUMAN
Alternative names:
-
Alternative UPACC:
O00178; Q6IC67
Background:
GTP-binding protein 1 plays a crucial role in cellular processes by promoting the degradation of target mRNA species. It is instrumental in the regulation of circadian mRNA stability, ensuring the precise timing of gene expression critical for circadian rhythms. This protein binds GTP and exhibits GTPase activity, indicating its involvement in signal transduction pathways.
Therapeutic significance:
Understanding the role of GTP-binding protein 1 could open doors to potential therapeutic strategies. Its pivotal function in mRNA stability and circadian rhythm regulation presents a unique opportunity for developing treatments targeting disorders related to these processes.