Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O00294
UPID:
TULP1_HUMAN
Alternative names:
Tubby-like protein 1
Alternative UPACC:
O00294; O43536; Q5TGM5; Q8N571
Background:
Tubby-related protein 1, alternatively known as Tubby-like protein 1, plays a crucial role in the development of photoreceptor synapses and the long-term survival of photoreceptor cells. It interacts with cytoskeleton proteins, aiding in protein transport within photoreceptor cells, and binds various lipids, which may influence cellular signaling pathways.
Therapeutic significance:
Linked to Retinitis pigmentosa 14 and Leber congenital amaurosis 15, Tubby-related protein 1's understanding could pave the way for innovative treatments for these retinal dystrophies. Its involvement in photoreceptor cell function and survival highlights its potential as a therapeutic target.