Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O00303
UPID:
EIF3F_HUMAN
Alternative names:
Deubiquitinating enzyme eIF3f; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47
Alternative UPACC:
O00303; A8K0S2; Q6IB45; Q8N978
Background:
Eukaryotic translation initiation factor 3 subunit F (eIF3f) plays a crucial role in the initiation of protein synthesis by forming part of the eIF-3 complex. This complex is essential for several steps in the initiation process, including mRNA recruitment and scanning for AUG recognition. eIF3f is also involved in the regulation of cell proliferation, differentiation, and apoptosis through its specific targeting and initiation of translation of certain mRNAs.
Therapeutic significance:
The association of eIF3f with Intellectual developmental disorder, autosomal recessive 67, highlights its potential as a target for therapeutic intervention. Understanding the role of eIF3f could open doors to potential therapeutic strategies.