Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O00337
UPID:
S28A1_HUMAN
Alternative names:
Concentrative nucleoside transporter 1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1
Alternative UPACC:
O00337; A0AV42; A8K7I2; O00335; O00336; Q5U5S6; Q5U648; Q9UEZ9
Background:
Sodium/nucleoside cotransporter 1, also known as Concentrative nucleoside transporter 1, plays a crucial role in cellular metabolism by facilitating the import of uridine, thymidine, and cytidine into cells. This process is vital for nucleic acid synthesis, leveraging the sodium electrochemical gradient across the plasma membrane. The protein's ability to also transport adenosine, albeit with different kinetics, underscores its versatility and importance in nucleoside homeostasis.
Therapeutic significance:
Given its role in nucleoside transport, Sodium/nucleoside cotransporter 1 is linked to Uridine-cytidineuria, a metabolic condition with increased urinary excretion of uridine and cytidine. Understanding the function of Sodium/nucleoside cotransporter 1 could pave the way for novel therapeutic approaches in managing metabolic disorders and enhancing nucleoside-based therapies.