Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O00423
UPID:
EMAL1_HUMAN
Alternative names:
-
Alternative UPACC:
O00423; Q86U15; Q8N536; Q8N5C4; Q8WWL6
Background:
Echinoderm microtubule-associated protein-like 1 plays a pivotal role in brain development by modulating the assembly and organization of the microtubule cytoskeleton. It is essential for the proper orientation of the mitotic spindle and cell division plane, influencing neuronal progenitor cell proliferation and brain formation.
Therapeutic significance:
Linked to Band heterotopia, a brain malformation due to disordered neuronal migration, this protein's understanding could pave the way for innovative treatments targeting brain development disorders.