Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O00488
UPID:
ZN593_HUMAN
Alternative names:
Zinc finger protein T86
Alternative UPACC:
O00488; B2R4S0; Q5T2H7
Background:
Zinc finger protein 593, also known as Zinc finger protein T86, plays a crucial role in cellular processes. It is involved in the maturation of pre-60S ribosomal particles by facilitating their nuclear export, as indicated by research published in PubMed. Additionally, it negatively modulates the DNA binding activity of Oct-2, impacting its transcriptional regulatory activity.
Therapeutic significance:
Understanding the role of Zinc finger protein 593 could open doors to potential therapeutic strategies. Its involvement in ribosomal particle maturation and transcriptional regulation highlights its importance in cellular function and presents a unique opportunity for drug discovery.