Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O00519
UPID:
FAAH1_HUMAN
Alternative names:
Anandamide amidohydrolase 1; Fatty acid ester hydrolase; Oleamide hydrolase 1
Alternative UPACC:
O00519; D3DQ19; Q52M86; Q5TDF8
Background:
Fatty-acid amide hydrolase 1, also known as Anandamide amidohydrolase 1, plays a crucial role in the hydrolysis of endogenous amidated lipids, including the sleep-inducing lipid oleamide and the endocannabinoid anandamide. This enzyme is pivotal in regulating the signaling functions of these molecules, with a preference for polyunsaturated substrates like anandamide over monounsaturated substrates.
Therapeutic significance:
Understanding the role of Fatty-acid amide hydrolase 1 could open doors to potential therapeutic strategies. Its involvement in the regulation of signaling molecules suggests its potential as a target for modulating physiological processes related to sleep and endocannabinoid signaling.