Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O14495
UPID:
PLPP3_HUMAN
Alternative names:
Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; Vascular endothelial growth factor and type I collagen-inducible protein
Alternative UPACC:
O14495; B2R651; D3DQ52; Q5U0F7; Q96GW0; Q99782
Background:
Phospholipid phosphatase 3, known by names such as Lipid phosphate phosphohydrolase 3 and Phosphatidic acid phosphatase 2b, plays a pivotal role in cellular processes by catalyzing the dephosphorylation of various lipid phosphate esters. This enzyme is crucial for the regulation of signal transduction, impacting cell migration, adhesion, survival, and proliferation, particularly in the vascular system and cerebellum development.
Therapeutic significance:
Understanding the role of Phospholipid phosphatase 3 could open doors to potential therapeutic strategies. Its involvement in regulating endothelial cell functions and its potential role in the Wnt signaling pathway highlight its significance in angiogenesis and possibly tumor growth, suggesting avenues for therapeutic intervention.