Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O14531
UPID:
DPYL4_HUMAN
Alternative names:
Collapsin response mediator protein 3; UNC33-like phosphoprotein 4
Alternative UPACC:
O14531; B2RMQ1; D3DRG5; O00240; Q5T0Q7
Background:
Dihydropyrimidinase-related protein 4, also known as Collapsin response mediator protein 3 and UNC33-like phosphoprotein 4, plays a crucial role in the nervous system. It is essential for signaling by class 3 semaphorins, leading to cytoskeleton remodeling. This protein is pivotal in axon guidance, neuronal growth cone collapse, and cell migration, facilitating proper neural development and function.
Therapeutic significance:
Understanding the role of Dihydropyrimidinase-related protein 4 could open doors to potential therapeutic strategies. Its involvement in neuronal guidance and migration positions it as a key target for addressing neurological disorders and enhancing neural repair mechanisms.