Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O14561
UPID:
ACPM_HUMAN
Alternative names:
CI-SDAP; NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Alternative UPACC:
O14561; B2R4M1; Q9UNV1
Background:
Acyl carrier protein, mitochondrial, also known as CI-SDAP and NADH-ubiquinone oxidoreductase 9.6 kDa subunit, plays a pivotal role in fatty acid biosynthesis and mitochondrial respiratory chain function. It acts as a carrier for the growing fatty acid chain, facilitating electron transfer in the respiratory chain and participating in the assembly of iron-sulfur clusters, essential for mitochondrial iron-sulfur protein biogenesis.
Therapeutic significance:
Understanding the role of Acyl carrier protein, mitochondrial could open doors to potential therapeutic strategies.