Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O14625
UPID:
CXL11_HUMAN
Alternative names:
Beta-R1; H174; Interferon gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; Small-inducible cytokine B11
Alternative UPACC:
O14625; Q53YA3; Q92840
Background:
C-X-C motif chemokine 11, known by alternative names such as Beta-R1, H174, and Interferon gamma-inducible protein 9, plays a pivotal role in immune responses. It is chemotactic for interleukin-activated T-cells, induces calcium release in activated T-cells, and binds to CXCR3, highlighting its significance in immune regulation.
Therapeutic significance:
Understanding the role of C-X-C motif chemokine 11 could open doors to potential therapeutic strategies. Its involvement in T-cell recruitment suggests its potential in targeting CNS diseases and skin immune responses, offering a promising avenue for therapeutic intervention.