Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O14640
UPID:
DVL1_HUMAN
Alternative names:
DSH homolog 1
Alternative UPACC:
O14640; Q5TA33; Q5TA35
Background:
Segment polarity protein dishevelled homolog DVL-1, also known as DSH homolog 1, is a pivotal component in the Wnt signaling pathway. It binds to the cytoplasmic C-terminus of frizzled family members, facilitating both canonical and non-canonical Wnt signaling. This protein is essential for LEF1 activation through WNT1 and WNT3A signaling and plays a critical role in the neuromuscular junction formation by forming a ternary complex with DVL1 and PAK1.
Therapeutic significance:
DVL-1's involvement in Robinow syndrome, autosomal dominant 2, a rare skeletal dysplasia syndrome, underscores its therapeutic significance. Understanding the role of DVL-1 could open doors to potential therapeutic strategies for treating this condition, which is characterized by distinctive dysmorphic features, limb shortening, and renal anomalies.