Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O14653
UPID:
GOSR2_HUMAN
Alternative names:
27 kDa Golgi SNARE protein; Membrin
Alternative UPACC:
O14653; D3DXJ5; D3DXJ6; Q8N4B8; Q96DA5; Q9BZZ4
Background:
Golgi SNAP receptor complex member 2, also known as Membrin and 27 kDa Golgi SNARE protein, plays a crucial role in the transport of proteins from the cis/medial-Golgi to the trans-Golgi network. Its unique function is pivotal in maintaining cellular homeostasis and protein processing.
Therapeutic significance:
Linked to diseases such as Epilepsy, progressive myoclonic 6, and congenital muscular dystrophy with or without seizures, understanding the role of Golgi SNAP receptor complex member 2 could open doors to potential therapeutic strategies. These conditions highlight the protein's significance in neurodevelopment and muscle function.