Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O14656
UPID:
TOR1A_HUMAN
Alternative names:
Dystonia 1 protein; Torsin ATPase-1A; Torsin family 1 member A
Alternative UPACC:
O14656; B2RB58; Q53Y64; Q96CA0
Background:
Torsin-1A, also known as Dystonia 1 protein or Torsin ATPase-1A, plays a pivotal role in protein folding, synaptic vesicle recycling, and the regulation of dopamine neurotransmission. Its involvement in the cellular trafficking and quality control of protein folding underscores its significance in maintaining cellular function and integrity.
Therapeutic significance:
Given its crucial role in diseases such as Dystonia 1, torsion, autosomal dominant, and Arthrogryposis multiplex congenita 5, Torsin-1A represents a promising target for therapeutic intervention. Understanding the role of Torsin-1A could open doors to potential therapeutic strategies.