Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O14737
UPID:
PDCD5_HUMAN
Alternative names:
TF-1 cell apoptosis-related protein 19
Alternative UPACC:
O14737; B4DE64; Q53YC9; Q6IB70
Background:
Programmed cell death protein 5, also known as TF-1 cell apoptosis-related protein 19, plays a crucial role in apoptosis. This protein, identified by the accession number O14737, is pivotal in regulating cell death, a fundamental process in cellular homeostasis and development.
Therapeutic significance:
Understanding the role of Programmed cell death protein 5 could open doors to potential therapeutic strategies. Its involvement in apoptosis makes it a key target for research in diseases where cell death is dysregulated.