Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O14775
UPID:
GNB5_HUMAN
Alternative names:
Gbeta5; Transducin beta chain 5
Alternative UPACC:
O14775; B2RBR5; Q9HAU9; Q9UFT3
Background:
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) plays a pivotal role in neuronal signaling and heart rate regulation. It enhances the activity of regulator of G protein signaling (RGS) proteins, crucial for terminating G protein-coupled receptor (GPCR) signaling. This action is vital for mood, cognition, and the deactivation of D(2) dopamine receptor signaling.
Therapeutic significance:
Gbeta5's involvement in intellectual developmental disorder with cardiac arrhythmia and language delay with ADHD suggests its potential as a therapeutic target. Understanding Gbeta5's role could open doors to novel treatments for these neurodevelopmental disorders.