Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O14893
UPID:
GEMI2_HUMAN
Alternative names:
Component of gems 2; Survival of motor neuron protein-interacting protein 1
Alternative UPACC:
O14893; B2R9W8; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79
Background:
Gem-associated protein 2, also known as Component of gems 2 or Survival of motor neuron protein-interacting protein 1, plays a pivotal role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential for pre-mRNA splicing. This process is crucial for the accurate removal of introns from pre-mRNA, ensuring the synthesis of correct and functional mRNA.
Therapeutic significance:
Understanding the role of Gem-associated protein 2 could open doors to potential therapeutic strategies.