Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O14957
UPID:
QCR10_HUMAN
Alternative names:
Complex III subunit 10; Complex III subunit XI; Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Alternative UPACC:
O14957; B2R542; D6W5Z4; Q9UEA3; Q9UPK4
Background:
Cytochrome b-c1 complex subunit 10, also known as Complex III subunit 10 or Ubiquinol-cytochrome c reductase complex 6.4 kDa protein, plays a pivotal role in the mitochondrial electron transport chain. This protein is a component of the ubiquinol-cytochrome c oxidoreductase, essential for oxidative phosphorylation. It facilitates the transfer of electrons from ubiquinol to cytochrome c, contributing to the creation of an electrochemical gradient crucial for ATP synthesis.
Therapeutic significance:
Understanding the role of Cytochrome b-c1 complex subunit 10 could open doors to potential therapeutic strategies.