Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O14966
UPID:
RAB7L_HUMAN
Alternative names:
Rab-7-like protein 1; Ras-related protein Rab-29
Alternative UPACC:
O14966; B4E1K3; C9JE77
Background:
Ras-related protein Rab-7L1, also known as Rab-7-like protein 1 or Ras-related protein Rab-29, plays a pivotal role in vesicle trafficking, ensuring the integrity of the endosome-trans-Golgi network. It is involved in the retrograde trafficking pathway, crucial for recycling proteins between lysosomes and the Golgi apparatus. Rab-7L1's interaction with LRRK2 enhances kinase activity, contributing to neuronal process morphology and potentially influencing typhoid toxin transport during Salmonella enterica infections.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-7L1 could open doors to potential therapeutic strategies.