Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O14994
UPID:
SYN3_HUMAN
Alternative names:
Synapsin III
Alternative UPACC:
O14994; B1B1F9
Background:
Synapsin-3, also known as Synapsin III, plays a crucial role in the nervous system. It is implicated in the regulation of neurotransmitter release and synaptogenesis, the process by which neurons form synapses with each other to transmit signals. This protein's function is vital for the proper communication between neurons, influencing learning, memory, and overall brain function.
Therapeutic significance:
Understanding the role of Synapsin-3 could open doors to potential therapeutic strategies. Its involvement in neurotransmitter release and synapse formation makes it a promising target for addressing neurological disorders and enhancing synaptic plasticity, which is crucial for learning and memory.