Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O15119
UPID:
TBX3_HUMAN
Alternative names:
-
Alternative UPACC:
O15119; Q8TB20; Q9UKF8
Background:
T-box transcription factor TBX3 plays a pivotal role in developmental processes, including limb pattern formation and mammary gland development. It functions as a transcriptional repressor by binding to specific DNA sequences, influencing gene regulation in various tissues. TBX3's involvement in lung and inner ear development, as well as its role in cellular senescence, underscores its multifaceted biological significance.
Therapeutic significance:
TBX3's mutation leads to Ulnar-mammary syndrome, characterized by limb, mammary gland, and other developmental abnormalities. Understanding TBX3's function and its genetic variants offers a pathway to targeted therapies for this syndrome, highlighting the protein's therapeutic potential.