Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O15266
UPID:
SHOX_HUMAN
Alternative names:
Pseudoautosomal homeobox-containing osteogenic protein; Short stature homeobox-containing protein
Alternative UPACC:
O15266; O00412; O00413; O15267
Background:
The Short stature homeobox protein, also known as Pseudoautosomal homeobox-containing osteogenic protein, plays a pivotal role in growth and development. Its alternative name, Short stature homeobox-containing protein, underscores its significance in stature determination.
Therapeutic significance:
Linked to Leri-Weill dyschondrosteosis, Langer mesomelic dysplasia, and idiopathic short stature, X-linked, this protein's understanding could pave the way for innovative treatments for these skeletal dysplasias.