Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O15287
UPID:
FANCG_HUMAN
Alternative names:
DNA repair protein XRCC9
Alternative UPACC:
O15287
Background:
The Fanconi anemia group G protein, also known as DNA repair protein XRCC9, plays a crucial role in DNA repair mechanisms. It is involved in postreplication repair or cell cycle checkpoint functions, contributing to interstrand DNA cross-link repair and chromosome stability. This protein is a candidate tumor suppressor gene, highlighting its importance in maintaining genomic integrity.
Therapeutic significance:
Fanconi anemia complementation group G, a disorder linked to this protein, affects bone marrow elements leading to various hematological issues and predisposes individuals to malignancies. Understanding the role of Fanconi anemia group G protein could open doors to potential therapeutic strategies, especially in enhancing DNA repair pathways and cancer prevention.