Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15394
UPID:
NCAM2_HUMAN
Alternative names:
-
Alternative UPACC:
O15394; A8MQ06; B7Z841; Q7Z7F2
Background:
Neural cell adhesion molecule 2 (NCAM2) is a pivotal protein that may play significant roles in the selective fasciculation and zone-to-zone projection of primary olfactory axons. This protein is essential for the proper development and function of the olfactory system, facilitating the precise wiring and connectivity of olfactory neurons.
Therapeutic significance:
Understanding the role of Neural cell adhesion molecule 2 could open doors to potential therapeutic strategies. Its involvement in the intricate processes of neuronal connectivity positions it as a key target for interventions in neurodevelopmental disorders.