Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15397
UPID:
IPO8_HUMAN
Alternative names:
Ran-binding protein 8
Alternative UPACC:
O15397; B7Z7M3
Background:
Importin-8, also known as Ran-binding protein 8, plays a crucial role in nuclear protein import. It functions either independently or as an adapter in association with the importin-beta subunit KPNB1. Importin-8 is pivotal for the translocation of import substrates through the nuclear pore complex, utilizing an energy-dependent, Ran-mediated mechanism. It facilitates the nuclear import of various cargos, including SRP19, Argonaute-microRNAs complexes, and SMAD transcription factors, essential for cellular signaling and regulation.
Therapeutic significance:
Importin-8's involvement in VISS syndrome, characterized by early-onset thoracic aortic aneurysm and immune dysregulation, underscores its potential as a therapeutic target. Understanding the role of Importin-8 could open doors to potential therapeutic strategies for managing this complex disease.