Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O43257
UPID:
ZNHI1_HUMAN
Alternative names:
Cyclin-G1-binding protein 1; Zinc finger protein subfamily 4A member 1; p18 Hamlet
Alternative UPACC:
O43257; Q6IB12
Background:
Zinc finger HIT domain-containing protein 1, also known as Cyclin-G1-binding protein 1 and p18 Hamlet, plays a pivotal role in chromatin remodeling and gene expression regulation. It facilitates the incorporation of histone variant H2AZ1 into the genome, influencing lymphoid lineage commitment, muscle differentiation, hematopoietic stem cell quiescence, and intestinal stem cell maintenance. Additionally, it contributes to cardiac function, mitochondrial maturation, neurite growth, and TP53/p53-mediated apoptosis.
Therapeutic significance:
Understanding the role of Zinc finger HIT domain-containing protein 1 could open doors to potential therapeutic strategies.