Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O43557
UPID:
TNF14_HUMAN
Alternative names:
Herpes virus entry mediator ligand
Alternative UPACC:
O43557; A8K7M2; C9J5H4; O75476; Q6FHA1; Q8WVF8; Q96LD2
Background:
Tumor necrosis factor ligand superfamily member 14 (TNFSF14), also known as Herpes virus entry mediator ligand, plays a pivotal role in immune regulation. It binds to TNFRSF3/LTBR and modulates effects through TNFRSF6B. Crucially, TNFSF14 interaction with TNFRSF14/HVEM stimulates T cell proliferation and IFNG production, highlighting its importance in immune responses.
Therapeutic significance:
Understanding the role of Tumor necrosis factor ligand superfamily member 14 could open doors to potential therapeutic strategies.