Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O43660
UPID:
PLRG1_HUMAN
Alternative names:
-
Alternative UPACC:
O43660; B3KMK4; Q3KQY5; Q8WUD8
Background:
Pleiotropic regulator 1 plays a crucial role in pre-mRNA splicing as a component of the spliceosome, according to research findings (PubMed:28502770, PubMed:28076346). It is part of the PRP19-CDC5L complex, essential for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). Additionally, it contributes to the splicing of U12-type introns in pre-mRNAs, highlighting its significance in the minor spliceosome.
Therapeutic significance:
Understanding the role of Pleiotropic regulator 1 could open doors to potential therapeutic strategies.