Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O43699
UPID:
SIGL6_HUMAN
Alternative names:
CD33 antigen-like 1; CDw327; Obesity-binding protein 1
Alternative UPACC:
O43699; A8MV71; B2RTS8; C9JBE5; F8WA78; O15388; O43700
Background:
Sialic acid-binding Ig-like lectin 6, known as CD33 antigen-like 1, CDw327, and Obesity-binding protein 1, is a putative adhesion molecule. It mediates sialic-acid dependent binding to cells, specifically binding to alpha-2,6-linked sialic acid. The sialic acid recognition site of this protein may be masked by cis interactions with sialic acids on the same cell surface, indicating a complex regulatory mechanism of action.
Therapeutic significance:
Understanding the role of Sialic acid-binding Ig-like lectin 6 could open doors to potential therapeutic strategies. Its unique sialic acid-binding capability suggests a pivotal role in cellular adhesion processes, which are crucial in many physiological and pathological contexts.